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1.
Braz J Cardiovasc Surg ; 38(6): e20230039, 2023 10 06.
Artigo em Inglês | MEDLINE | ID: mdl-37801566

RESUMO

INTRODUCTION: The increasing worldwide number of adults with congenital heart disease (CHD) demands greater attention from health professionals. The purpose of this report is to describe the clinical demographic profile, frequency, and invasive treatment status of adults with CHD in a public reference hospital in northeastern Brazil. METHODS: This is a retrospective cross-sectional study including 704 patients attended between August 2016 and August 2020. Data were collected from virtual database. RESULTS: Patients' age varied from 17 to 81 years (mean 32±14; median 27 years); 294 (41.8%) patients were male, and 410 (58,2%) were female; 230 (32,7%) had diagnosis from age 18 and up. Cardiac complexity categories were "simple defects" (134 [19%] patients), "moderate complexity" (503 [71.5%]), and "great complexity" (67 [9.5%]). Atrial septal defect (ASD) was diagnosed in 216 (30.7%) patients, ventricular septal defect (VSD) in 101 (14.3%), tetralogy of Fallot in 93 (13.2%), and other CHD in 294 (41.8%). New York Heart Association (NYHA) functional classes were I (401 [57%]), II (203 [28.8%]), III (76 [10.8%]), and IV (24 [3.4%]). Complications were arrhythmias (173 [24%]) and severe pulmonary hypertension (69 [9.8%]). Invasive treatments were corrective surgery (364 (51.6%]), reoperation (28 [4.0%]), palliation (11 [1.6%]), interventional catheterization (12 [1.7%]), surgery plus interventional catheterization (5 [0.7%]), and preoperation (91 [12.9%]). Treatment was not required in 102 (14,5%) patients, and 91 (12.9%) were inoperable. CONCLUSION: The leading diagnosis was ASD. Frequency of unrepaired patients was high, mainly ASD, due to late diagnosis, which favored complications and denotes a matter of great concern.


Assuntos
Cardiopatias Congênitas , Comunicação Interatrial , Tetralogia de Fallot , Adulto , Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Cardiopatias Congênitas/epidemiologia , Cardiopatias Congênitas/cirurgia , Cardiopatias Congênitas/complicações , Tetralogia de Fallot/cirurgia , Estudos Retrospectivos , Brasil/epidemiologia , Estudos Transversais , Comunicação Interatrial/cirurgia , Hospitais
2.
Rev. bras. cir. cardiovasc ; 38(6): e20230039, 2023. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1514979

RESUMO

ABSTRACT Introduction: The increasing worldwide number of adults with congenital heart disease (CHD) demands greater attention from health professionals. The purpose of this report is to describe the clinical demographic profile, frequency, and invasive treatment status of adults with CHD in a public reference hospital in northeastern Brazil. Methods: This is a retrospective cross-sectional study including 704 patients attended between August 2016 and August 2020. Data were collected from virtual database. Results: Patients' age varied from 17 to 81 years (mean 32±14; median 27 years); 294 (41.8%) patients were male, and 410 (58,2%) were female; 230 (32,7%) had diagnosis from age 18 and up. Cardiac complexity categories were "simple defects" (134 [19%] patients), "moderate complexity" (503 [71.5%]), and "great complexity" (67 [9.5%]). Atrial septal defect (ASD) was diagnosed in 216 (30.7%) patients, ventricular septal defect (VSD) in 101 (14.3%), tetralogy of Fallot in 93 (13.2%), and other CHD in 294 (41.8%). New York Heart Association (NYHA) functional classes were I (401 [57%]), II (203 [28.8%]), III (76 [10.8%]), and IV (24 [3.4%]). Complications were arrhythmias (173 [24%]) and severe pulmonary hypertension (69 [9.8%]). Invasive treatments were corrective surgery (364 (51.6%]), reoperation (28 [4.0%]), palliation (11 [1.6%]), interventional catheterization (12 [1.7%]), surgery plus interventional catheterization (5 [0.7%]), and preoperation (91 [12.9%]). Treatment was not required in 102 (14,5%) patients, and 91 (12.9%) were inoperable. Conclusion: The leading diagnosis was ASD. Frequency of unrepaired patients was high, mainly ASD, due to late diagnosis, which favored complications and denotes a matter of great concern.

3.
Acta Cir Bras ; 36(5): e360508, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34161435

RESUMO

PURPOSE: To develop and validate a chest cavity simulator for teaching video-assited thoracic surgery (VATS). METHODS: The first phase of the study consisted of developing a chest cavity simulator. A quasi-experimental study was performed in the second phase, and 25 surgeons and residents participated in a three-stage pulmonary suture experiment. The videos were recorded and timed. Generalized linear regression models for repeated measures were used to analyze the outcome change over time. RESULTS: The chest cavity simulator consists of a console simulating the left hemithorax. Among the participants, 96% rated the design, visual aspect, positioning ergonomics, and triangulation of the portals as very good or excellent (face validity). There was a decrease in suturing time in step 1 from 435.7 ± 105 to 355.6 ± 76.8 seconds compared to step 3 (p = 0.001). The evaluation of the simulation effectiveness and performance (content validity) was rated as very good or excellent by 96% ofparticipants. The most experienced surgeon showed significant reduction in procedure time (p = 0.021) (construct validity). CONCLUSIONS: The thoracic cavity simulator is realistic, showing content and construct validity, and can be used in VATS training. The simulation model allowed skill gain in the endoscopic suture.


Assuntos
Treinamento por Simulação , Cirurgia Torácica , Brasil , Competência Clínica , Simulação por Computador , Endoscopia , Reprodutibilidade dos Testes
4.
Acta cir. bras ; 36(5): e360508, 2021. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1278108

RESUMO

ABSTRACT Purpose To develop and validate a chest cavity simulator for teaching video-assited thoracic surgery (VATS). Methods The first phase of the study consisted of developing a chest cavity simulator. A quasi-experimental study was performed in the second phase, and 25 surgeons and residents participated in a three-stage pulmonary suture experiment. The videos were recorded and timed. Generalized linear regression models for repeated measures were used to analyze the outcome change over time. Results The chest cavity simulator consists of a console simulating the left hemithorax. Among the participants, 96% rated the design, visual aspect, positioning ergonomics, and triangulation of the portals as very good or excellent (face validity). There was a decrease in suturing time in step 1 from 435.7 ± 105 to 355.6 ± 76.8 seconds compared to step 3 (p = 0.001). The evaluation of the simulation effectiveness and performance (content validity) was rated as very good or excellent by 96% ofparticipants. The most experienced surgeon showed significant reduction in procedure time (p = 0.021) (construct validity). Conclusions The thoracic cavity simulator is realistic, showing content and construct validity, and can be used in VATS training. The simulation model allowed skill gain in the endoscopic suture.


Assuntos
Cirurgia Torácica , Treinamento por Simulação , Simulação por Computador , Brasil , Reprodutibilidade dos Testes , Competência Clínica , Endoscopia
5.
Braz J Cardiovasc Surg ; 34(3): 271-278, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31310464

RESUMO

OBJECTIVE: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. METHODS: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. RESULTS: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. CONCLUSION: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.


Assuntos
Soluções Cardioplégicas/uso terapêutico , Cardiopatias Congênitas/cirurgia , Análise de Variância , Creatina Quinase Forma MB/análise , Método Duplo-Cego , Ecocardiografia , Feminino , Glucose/uso terapêutico , Cardiopatias Congênitas/fisiopatologia , Humanos , Lactente , Recém-Nascido , Masculino , Manitol/uso terapêutico , Duração da Cirurgia , Cloreto de Potássio/uso terapêutico , Procaína/uso terapêutico , Estudos Prospectivos , Substâncias Protetoras/uso terapêutico , Valores de Referência , Reprodutibilidade dos Testes , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento , Troponina/análise , Função Ventricular Esquerda
6.
Rev. bras. cir. cardiovasc ; 34(3): 271-278, Jun. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1013463

RESUMO

Abstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Soluções Cardioplégicas/uso terapêutico , Cardiopatias Congênitas/cirurgia , Cloreto de Potássio/uso terapêutico , Procaína/uso terapêutico , Valores de Referência , Fatores de Tempo , Troponina/análise , Ecocardiografia , Método Duplo-Cego , Estudos Prospectivos , Reprodutibilidade dos Testes , Análise de Variância , Função Ventricular Esquerda , Resultado do Tratamento , Estatísticas não Paramétricas , Substâncias Protetoras/uso terapêutico , Creatina Quinase Forma MB/análise , Duração da Cirurgia , Glucose/uso terapêutico , Cardiopatias Congênitas/fisiopatologia , Manitol/uso terapêutico
8.
Rev. bras. cir. cardiovasc ; 28(4): 545-549, out.-dez. 2013. ilus
Artigo em Português | LILACS | ID: lil-703125

RESUMO

A estenose aórtica supravalvar é uma rara cardiopatia congênita, bastante incomum em adultos. Apresentamos um caso de estenose aórtica supravalvar em adulto com anomalia de vasos do arco aórtico, já com presença de insuficiência aórtica importante, tratado com êxito por meio de plastia da aorta ascendente e troca valvar aórtica.


The supravalvular aortic stenosis is a rare congenital heart defect being very uncommon in adults. We present a case of supravalvular aortic stenosis in adult associated with anomalies of the aortic arch vessels and aortic regurgitation, which was submitted to aortic valve replacement and arterioplasty of the ascending aorta with a good postoperative course.


Assuntos
Adulto , Humanos , Masculino , Aorta Torácica/cirurgia , Estenose Aórtica Supravalvular/cirurgia , Insuficiência da Valva Aórtica/cirurgia , Aorta Torácica/patologia , Estenose Aórtica Supravalvular/patologia , Insuficiência da Valva Aórtica/patologia , Tronco Braquiocefálico/patologia , Tronco Braquiocefálico/cirurgia , Angiografia Coronária , Próteses Valvulares Cardíacas , Artéria Subclávia/patologia , Artéria Subclávia/cirurgia , Resultado do Tratamento
9.
Rev Bras Cir Cardiovasc ; 28(4): 545-9, 2013.
Artigo em Inglês, Português | MEDLINE | ID: mdl-24598962

RESUMO

The supravalvular aortic stenosis is a rare congenital heart defect being very uncommon in adults. We present a case of supravalvular aortic stenosis in adult associated with anomalies of the aortic arch vessels and aortic regurgitation, which was submitted to aortic valve replacement and arterioplasty of the ascending aorta with a good postoperative course.


Assuntos
Aorta Torácica/cirurgia , Estenose Aórtica Supravalvular/cirurgia , Insuficiência da Valva Aórtica/cirurgia , Adulto , Aorta Torácica/patologia , Estenose Aórtica Supravalvular/patologia , Insuficiência da Valva Aórtica/patologia , Tronco Braquiocefálico/patologia , Tronco Braquiocefálico/cirurgia , Angiografia Coronária , Próteses Valvulares Cardíacas , Humanos , Masculino , Artéria Subclávia/patologia , Artéria Subclávia/cirurgia , Resultado do Tratamento
10.
Rev Bras Cir Cardiovasc ; 24(3): 327-33, 2009.
Artigo em Inglês, Português | MEDLINE | ID: mdl-20011878

RESUMO

OBJECTIVE: Although pulmonary artery banding (PAB) seems to be a technically simple procedure it presents several peculiarities and is related to a significant morbidity and mortality. The aim of this study is to analyze the experience of a tertiary hospital on the PAB by assessing and correlating many aspects related to the procedure. METHODS: Between January 2000 and December 2008, 61 patients undergone PAB due to congenital heart disease with increased pulmonary blood flow at Messejana Heart Hospital were assessed as for mortality, complications, stay in mechanical ventilation and need for intensive care unit (ICU), use of vasoactive drugs, difficulties in the adjustment on the banding and reoperations. Some statistical analyzes were performed to compare the subgroups. RESULTS: In 46.8% of the patients the intended pressoric adjustment was not achieved and in 6.5% it was necessary another surgery to readjust the banding. The mean time of mechanical ventilation was 14.1+/-49.6 days and ICU 14.16+/-10.92 days. In 82.6% of the patients vasoactives drugs were administrated for 10.3+/-12.79 days. Severe complications were noted in 49.15% of patients and cardiac insufficiency was the most common one with an incidence of 44%. The mortality rate was 8.2% and it was not influenced by weight or associated procedures with the PAB neither if univentricular or biventricular heart disease. CONCLUSION: The PAB can be performed with acceptable mortality rates compatible with the ones of the world literature. Nevertheless, the adjustment of the banding is difficult to be assessed during the surgery by making the procedure complex and justifying the high incidence of complications and long stay in ICU. It wasn't found any specific risk factor significant to mortality neither uni- or biventricular heart disease.


Assuntos
Procedimentos Cirúrgicos Cardiovasculares/métodos , Cardiopatias Congênitas/cirurgia , Artéria Pulmonar/cirurgia , Procedimentos Cirúrgicos Cardiovasculares/efeitos adversos , Distribuição de Qui-Quadrado , Humanos , Lactente , Masculino
11.
Rev. bras. cir. cardiovasc ; 24(3): 327-333, jul.-set. 2009. ilus, tab
Artigo em Português | LILACS | ID: lil-533261

RESUMO

OBJETIVO: A bandagem da artéria pulmonar (BAP) é um procedimento tecnicamente simples, mas envolto em várias peculiaridades que o fazem apresentar elevadas taxas de morbidade e mortalidade. O objetivo deste estudo é analisar a experiência de um hospital de referência na bandagem da artéria pulmonar, avaliando e correlacionando diversas variáveis relacionadas ao procedimento. MÉTODOS: Entre janeiro de 2000 e dezembro de 2008, 61 pacientes submetidos a BAP por cardiopatia congênita de hiperfluxo no Hospital do Coração de Messejana-Fortaleza/CE foram avaliados quanto a mortalidade, complicações, permanência em ventilação mecânica (VM) e terapia intensiva (UTI), uso de drogas vasoativas, dificuldade de ajustes transoperatórios e reoperações para reajuste. Análise estatística foi realizada para comparações entre subgrupos. RESULTADOS: Em 46,8 por cento dos pacientes, não se conseguiu o ajuste pressórico pretendido e 6,5 por cento precisaram ser reoperados para reajustes. O tempo médio UTI e VM foi 14,16 ± 10,92 dias e 14,1 ± 49,6 dias, respectivamente. Em 82,6 por cento dos pacientes foram administradas drogas vasoativas por 10,30 ± 12,79 dias. Complicações graves incidiram em 49,15 por cento dos pacientes, com predominância da insuficiência cardíaca (44 por cento). A taxa de mortalidade foi de 8,2 por cento, não influenciada por peso, procedimentos associados ou cardiopatia univentricular ou biventricular. CONCLUSÃO: Neste estudo, a BAP foi realizada com taxas de mortalidade aceitáveis, compatíveis com a literatura mundial. No entanto, os ajustes transoperatórios são de difícil análise, tornando o procedimento complexo e justificando elevados índices de complicações, resultando em longa permanência em UTI. Nenhuma variável isolada representou significante fator de risco, dentre as quais, fisiologia uni ou biventricular


OBJECTIVE: Although pulmonary artery banding (PAB) seems to be a technically simple procedure it presents several peculiarities and is related to a significant morbidity and mortality. The aim of this study is to analyze the experience of a tertiary hospital on the PAB by assessing and correlating many aspects related to the procedure. METHODS: Between January 2000 and December 2008, 61 patients undergone PAB due to congenital heart disease with increased pulmonary blood flow at Messejana Heart Hospital were assessed as for mortality, complications, stay in mechanical ventilation and need for intensive care unit (ICU), use of vasoactive drugs, difficulties in the adjustment on the banding and reoperations. Some statistical analyzes were performed to compare the subgroups. RESULTS: In 46.8 percent of the patients the intended pressoric adjustment was not achieved and in 6.5 percent it was necessary another surgery to readjust the banding. The mean time of mechanical ventilation was 14.1±49.6 days and ICU 14.16±10.92 days. In 82.6 percent of the patients vasoactives drugs were administrated for 10.3±12.79 days. Severe complications were noted in 49.15 percent of patients and cardiac insufficiency was the most common one with an incidence of 44 percent. The mortality rate was 8.2 percent and it was not influenced by weight or associated procedures with the PAB neither if univentricular or biventricular heart disease. CONCLUSION: The PAB can be performed with acceptable mortality rates compatible with the ones of the world literature. Nevertheless, the adjustment of the banding is difficult to be assessed during the surgery by making the procedure complex and justifying the high incidence of complications and long stay in ICU. It wasn't found any specific risk factor significant to mortality neither uni- or biventricular heart disease


Assuntos
Humanos , Lactente , Masculino , Procedimentos Cirúrgicos Cardiovasculares/métodos , Cardiopatias Congênitas/cirurgia , Artéria Pulmonar/cirurgia , Distribuição de Qui-Quadrado , Procedimentos Cirúrgicos Cardiovasculares/efeitos adversos
12.
Rev Bras Cir Cardiovasc ; 23(1): 60-9, 2008.
Artigo em Português | MEDLINE | ID: mdl-18719830

RESUMO

OBJECTIVES: Adjustable pulmonary trunk (PT) banding device may induce a more physiologic ventricle retraining for the two-stage Jatene operation. This experimental study evaluates the acute hypertrophy (96 hours) of the right ventricle (RV) submitted to an intermittent pressure overload. METHODS: Five groups of seven young goats were distributed according to RV intermittent systolic overload duration (0, 24, 48, 72 and 96 hours). The zero-hour group served as a control group. Echocardiographic and hemodynamic evaluations were performed daily. After completing the training program for each group, the animals were sacrificed for water content and cardiac masses evaluation. RESULTS: There was a significant increase in RV free wall thickness starting with the 48-hour group (p<0.05). However, a decreased RV ejection fraction, associated with an important RV dilation and a significant increase in the RV volume to mass ratio was observed at 24-hour training period, when compared to 96-hour period (p=0.003), with subsequent recovery throughout the protocol. A 104.7% increase in RV mass was observed in the 96-hour group, as compared to the control group, with no differences in water content between these two groups. The daily mean increase in RV mass during the study period was 21.6% +/- 26.8%. The rate of RV mass acquisition for the overall study period of intermittent systolic overload was 0.084 g/h +/- 0.035 g/h. CONCLUSION: Intermittent PT banding has allowed a significant RV mass acquisition in the 96-hour trained group. No myocardial water content changes were observed in this group, suggesting an increased myocardial protein synthesis.


Assuntos
Hipertrofia Ventricular Direita/fisiopatologia , Modelos Cardiovasculares , Transposição dos Grandes Vasos/cirurgia , Animais , Modelos Animais de Doenças , Cabras , Ventrículos do Coração/fisiopatologia , Hemodinâmica , Ligadura , Tamanho do Órgão , Sístole/fisiologia , Função Ventricular Direita/fisiologia
13.
Rev. bras. cir. cardiovasc ; 23(1): 60-69, jan.-mar. 2008. ilus
Artigo em Inglês, Português | LILACS | ID: lil-489701

RESUMO

OBJETIVO: A bandagem ajustável do tronco pulmonar (TP) pode proporcionar treinamento ventricular mais fisiológico para cirurgia de Jatene em dois estágios. Este estudo experimental analisa a hipertrofia aguda (96 horas) do ventrículo direito (VD) submetido à sobrecarga sistólica intermitente. MÉTODOS: Cinco grupos de sete cabritos jovens foram dispostos conforme o tempo de sobrecarga sistólica do VD (0, 24, 48, 72 e 96 horas). O grupo zero hora funcionou como grupo controle. Avaliações ecocardiográficas e hemodinâmicas foram feitas diariamente. Os animais foram sacrificados para avaliação do conteúdo de água e pesagem das massas cardíacas. RESULTADOS: Houve aumento da espessura do VD a partir de 48 horas de treinamento (p<0,05) e rebaixamento da fração de ejeção do VD, com dilatação importante desta câmara nas primeiras 24 horas do protocolo, recuperando-se posteriormente. Houve aumento da relação volume/massa nas primeiras 24 horas do protocolo, em relação ao momento 96 horas (p=0,003). A massa do VD apresentou aumento de 104,7 por cento no grupo 96 horas em relação ao controle. Não houve diferença quanto ao conteúdo de água do VD. A média diária de aumento da massa do VD foi de 21,6 por cento ± 26,8 por cento. A taxa de ganho de massa muscular do VD para todo o período de estudo foi de 0,084 g/h ± 0,035 g/h. CONCLUSÃO: O protocolo de bandagem intermitente do TP permitiu ganho de massa muscular do VD, significativa no grupo de 96 horas de estudo. Esta hipertrofia não foi acompanhada de aumento no conteúdo de água, o que sugere maior síntese protéica nos tecidos cardíacos.


OBJECTIVES: Adjustable pulmonary trunk (PT) banding device may induce a more physiologic ventricle retraining for the two-stage Jatene operation. This experimental study evaluates the acute hypertrophy (96 hours) of the right ventricle (RV) submitted to an intermittent pressure overload. METHODS: Five groups of seven young goats were distributed according to RV intermittent systolic overload duration (0, 24, 48, 72 and 96 hours). The zero-hour group served as a control group. Echocardiographic and hemodynamic evaluations were performed daily. After completing the training program for each group, the animals were sacrificed for water content and cardiac masses evaluation. RESULTS: There was a significant increase in RV free wall thickness starting with the 48-hour group (p<0.05). However, a decreased RV ejection fraction, associated with an important RV dilation and a significant increase in the RV volume to mass ratio was observed at 24-hour training period, when compared to 96-hour period (p=0.003), with subsequent recovery throughout the protocol. A 104.7 percent increase in RV mass was observed in the 96-hour group, as compared to the control group, with no differences in water content between these two groups. The daily mean increase in RV mass during the study period was 21.6 percent ± 26.8 percent. The rate of RV mass acquisition for the overall study period of intermittent systolic overload was 0.084 g/h ± 0.035 g/h. CONCLUSION: Intermittent PT banding has allowed a significant RV mass acquisition in the 96-hour trained group. No myocardial water content changes were observed in this group, suggesting an increased myocardial protein synthesis.


Assuntos
Animais , Hipertrofia Ventricular Direita/fisiopatologia , Modelos Cardiovasculares , Transposição dos Grandes Vasos/cirurgia , Modelos Animais de Doenças , Cabras , Hemodinâmica , Ventrículos do Coração/fisiopatologia , Ligadura , Tamanho do Órgão , Sístole/fisiologia , Função Ventricular Direita/fisiologia
14.
Rev. bras. cir. cardiovasc ; 21(4): 418-428, out.-dez. 2006. graf, tab
Artigo em Português | LILACS | ID: lil-442533

RESUMO

OBJETIVO: Este estudo compara a sobrecarga contínua versus intermitente do ventrículo direito (VD) de cabritos, para induzir a hipertrofia ventricular. MÉTODO: Foram utilizados três grupos de sete cabritos jovens (controle, contínuo, intermitente). A sobrecarga sistólica foi imposta por 96 horas, no contínuo e por quatro períodos de 12 horas, alternados com 12 horas de descanso, no intermitente. Avaliações ecocardiográficas e hemodinâmicas foram feitas diariamente. Os animais foram, então, mortos para avaliar o conteúdo de água e peso das massas cardíacas. RESULTADOS: O Intermitente mostrou aumento dos pesos de VD e de septo, em relação ao controle (p<0,05), enquanto o contínuo aumentou apenas a massa do VD (p<0,05). Houve maior aumento da espessura do VD no Intermitente (p<0,05). O volume diastólico final do VD mostrou diferença significativa entre os grupos (p=0,01), com maior dilatação do VD do grupo contínuo, no momento 24 horas de sobrecarga sistólica (p<0,03). A fração de ejeção do VD se manteve dentro da normalidade nos dois grupos ao longo do protocolo. Foi observado menor perímetro do VD no intermitente, após 96 horas de treinamento (p<0,05). Não houve diferença significante entre os grupos de estudo e o controle quanto ao conteúdo de água do miocárdio do VD. CONCLUSÃO: A bandagem ajustável do tronco pulmonar permitiu um rápido processo hipertrófico do VD em ambos os grupos, sendo, porém, mais eficiente no intermitente. Nosso estudo sugere que a preparação do ventrículo subpulmonar de forma intermitente poderá proporcionar melhor resultado para a operação de Jatene em dois estágios.


OBJECTIVE: This study compares ventricular hypertrophy induced by continuous versus intermittent systolic overload of the pulmonary ventricle (RV) of young goats. METHODS: Three groups of seven goats were used (control, continuous, and intermittent). Systolic overload was maintained for 96 hours in the continuous group, while the intermittent group suffered four 12-hour periods of systolic overload, alternating with 12-hour resting periods. Echocardiographic and hemodynamic evaluations were performed every day. The animals were then killed for myocardial water content and weight evaluation. RESULTS: Both study groups achieved significant increases in RV mass (p<0.05). However, significant increases of the septum mass were observed only in the Intermittent Group (p<0.05). A greater increase in the RV wall thickness was observed in the Intermittent Group (p<0.05). There was a significant difference in RV diastolic volume between the two groups (p= 0.01), with a greater RV dilation in the Continuous Group after 24 hours of continuous overload (p< 0.03). In both groups, the RV ejection fraction was maintained within the normal range throughout the protocol. A smaller RV perimeter was observed in the Intermittent Group after 96 hours of systolic overload (p<0.05). There was no significant difference in RV myocardial water content between the study groups and the Control Group. CONCLUSIONS: Adjustable pulmonary artery bandages permit rapid RV hypertrophy in both groups. Nevertheless, it is more efficient in the Intermittent Group. This study suggests that preparation of the pulmonary ventricle with intermittent systolic overload might provide better results for the 2-stage arterial switch operation.


Assuntos
Animais , Transposição dos Grandes Vasos , Hipertrofia Ventricular Direita , Cabras , Procedimentos Cirúrgicos Cardíacos
15.
Rev. bras. cir. cardiovasc ; 16(1): 49-52, jan.-mar. 2001.
Artigo em Português | LILACS | ID: lil-289380

RESUMO

Introduçäo/Objetivo: O implante de marcapasso cardíaco definitivo é um procedimento caracterizado por um baixo índice de complicaçöes. No entanto, a infecçäo, principalmente a de loja de fonte geradora, caracteriza-se como uma das complicaçöes mais comuns, com incidências variando entre 1-5 por cento na maioria dos centros. Diversas abordagens terapêuticas para o tratamento desta afecçäo vêm sendo descritas com resultados controversos. Observa-se, entretanto, uma tendência a melhores resultados, com menores índices de falência de tratamento ou reinfecçäo, nas abordagens mais agressivas, estas sempre relacionadas à alta morbidade e a altos custos finais. Com base nos princípios já bem descritos do poder bactericida dos flaps musculocutâneos associados à antibioticoterapia na esterilizaçäo de áreas pouco vascularizadas infectadas, foi desenvolvida e avaliada neste estudo inicial a técnica de implante subpeitoral para o tratamento dos casos de infecçäo restrita de loja de fonte geradora, objetivando-se menores morbidades e custos com, bons resultados. Casuística e Método: Foi considerado no presente estudo o período de janeiro de 1996 a março de 2000 onde foram realizados 574 procedimentos, entre implantes e trocas de fontes geradoras, na Santa Casa de Säo Paulo, com um índice de infecçäo de 1,11 por cento (6 casos) e 2 casos de extrusäo de fonte geradora sem infecçäo aparente. Quatro casos tratavam-se de infecçäo exclusiva de loja de fonte e em 2 casos houve comprometimento sistêmico com sepse. Os germes infectantes foram S.aureus, S.epidermidis e Pseudomonas. Foi utilizada como abordagem terapêutica para todos os casos sem comprometimento sistêmico a técnica de implante subpeitoral da mesma fonte geradora associada à antibioticoterapia específica. Resultados: Näo houve óbitos, casos de reinfecçäo ou falência de tratamento nos pacientes submetidos à técnica. O tempo médio de internaçäo foi 7,3 dias. O tempo médio de antibioticoterapia foi de 7 dias. Näo houve distúrbios do marcapasso que exigissem reabordagem. O seguimento é de 5 meses a 4 anos. Conclusäo: A técnica avaliada mostra-se, a princípio, como uma alternativa viável no tratamento da infecçäo de loja de marcapasso, com baixa morbidade e grande eficácia


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Infecções Bacterianas/terapia , Marca-Passo Artificial/efeitos adversos , Idoso de 80 Anos ou mais , Infecções Bacterianas/etiologia
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